Rab 1B Polyclonal Antibody

    • Catalog No.:YT3921
    • Applications:WB,ELISA
    • Reactivity:Human,Mouse,Rat
      • Gene Name:
      • RAB1B
      • Protein Name:
      • Ras-related protein Rab-1B
      • Human Swiss Prot No:
      • Q9H0U4
      • Mouse Swiss Prot No:
      • Q9D1G1
      • Immunogen:
      • Synthesized peptide derived from Rab 1B . at AA range: 50-130
      • Specificity:
      • Rab 1B Polyclonal Antibody detects endogenous levels of Rab 1B protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Rabbit
      • Dilution:
      • Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • RAB1B; Ras-related protein Rab-1B
      • MolecularWeight(Da):
      • 22171
      • Observed Band(KD):
      • 22
      • Background:
      • RAB1B, member RAS oncogene family(RAB1B) Homo sapiens Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009],
      • Function:
      • function:Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments.,miscellaneous:Rab-1B binds GTP and GDP and possesses intrinsic GTPase activity.,PTM:Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1).,similarity:Belongs to the small GTPase superfamily. Rab family.,subcellular location:Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm.,subunit:Interacts with MICAL1, MICAL2 and MICAL3. Interacts with GDI1; the interaction requires the GDP-bound state. Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II.,
      • Subcellular Location:
      • Golgi membrane,intracellular,mitochondrion,endoplasmic reticulum membrane,Golgi apparatus,transport vesicle,endoplasmic reticulum-Golgi intermediate compartment membrane,pre-autophagosomal structure membrane,extracellular exosome,
      • Expression:
      • B-cell lymphoma,Brain,Muscle,Pancreas,
      • Products Images
      • Western blot analysis of lysates from SH-SY5Y cells, primary antibody was diluted at 1:1000, 4°over night