• Target：
• NGEP

• Gene Name：
• ANO7

• Protein Name：
• Anoctamin-7

• Human Gene Id：
• 50636

• Human Swiss Prot No：
• Q6IWH7

• Mouse Swiss Prot No：
• Q14AT5

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TM16G. AA range:881-930

• Specificity：
• NGEP Polyclonal Antibody detects endogenous levels of NGEP protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ANO7;NGEP;PCANAP5;TMEM16G;Anoctamin-7;Dresden transmembrane protein of the prostate;D-TMPP;IPCA-5;New gene expressed in prostate;Prostate cancer-associated protein 5;Transmembrane protein 16G

• Observed Band(KD)：
• 105kD

• Background：
• This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2011],

• Function：
• caution:It is uncertain whether Met-1 or Met-55 is the initiator.,function:May act as a calcium-activated chloride channel. May play a role in cell-cell interactions.,induction:Up-regulated by androgen.,similarity:Belongs to the anoctamin family.,subcellular location:Concentrates at sites of cell-cell contact.,tissue specificity:Specifically expressed in epithelial cells of the prostate (at protein level).,

• Subcellular Location：
• [Isoform 1]: Cell membrane ; Multi-pass membrane protein . Cell junction . Endoplasmic reticulum . Concentrates at sites of cell-cell contact (PubMed:17308099). Shows an intracellular localization according to PubMed:22075693 and PubMed:20056604. .; [Isoform 2]: Cytoplasm, cytosol .

• Expression：
• Specifically expressed in epithelial cells of the prostate (at protein level).

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