FRP-2 Polyclonal Antibody

    • Catalog No.:YT1790
    • Applications:WB,ELISA
    • Reactivity:Human,Mouse,Rat
    • Description
    • Gene Name:
    • SFRP2
    • Protein Name:
    • Secreted frizzled-related protein 2
    • Human Gene Id:
    • 6423
    • Human Swiss Prot No:
    • Q96HF1
    • Mouse Swiss Prot No:
    • P97299
    • Immunogen:
    • The antiserum was produced against synthesized peptide derived from human SFRP2. AA range:119-168
    • Specificity:
    • FRP-2 Polyclonal Antibody detects endogenous levels of FRP-2 protein.
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Rabbit
    • Dilution:
    • Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
    • Purification:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Other Name:
    • SFRP2; FRP2; SARP1; FKSG12; Secreted frizzled-related protein 2; FRP-2; sFRP-2; Secreted apoptosis-related protein 1; SARP-1
    • MolecularWeight(Da):
    • 33490
    • Observed Band(KD):
    • 30
    • Background:
    • secreted frizzled related protein 2(SFRP2) Homo sapiens This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008],
    • Function:
    • domain:The FZ domain is involved in binding with Wnt ligands.,function:Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.,similarity:Belongs to the secreted frizzled-related protein (sFRP) family.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 1 NTR domain.,tissue specificity:Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.,
    • Subcellular Location:
    • extracellular region,extracellular space,integral component of membrane,extracellular matrix,
    • Expression:
    • Epithelium,Eye,Trachea,
    • Products Images
    • Western Blot analysis of various cells using FRP-2 Polyclonal Antibody diluted at 1:500
    • Western Blot analysis of HuvEc cells using FRP-2 Polyclonal Antibody diluted at 1:500
    • Western blot analysis of lysates from HeLa, COLO, and HUVEC cells, using SFRP2 Antibody. The lane on the right is blocked with the synthesized peptide.