• Target：
• E-Ras

• Gene Name：
• ERAS

• Protein Name：
• GTPase Eras

• Human Gene Id：
• 3266

• Human Swiss Prot No：
• Q7Z444

• Mouse Swiss Prot No：
• Q7TN89

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human ERAS. AA range:184-233

• Specificity：
• E-Ras Polyclonal Antibody detects endogenous levels of E-Ras protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ERAS;HRAS2;HRASP;GTPase ERas;E-Ras;Embryonic stem cell-expressed Ras

• Observed Band(KD)：
• 25kD

• Background：
• This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012],

• Function：
• enzyme regulation:Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).,function:Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells.,similarity:Belongs to the small GTPase superfamily. Ras family.,subunit:Interacts with PIK3CD.,

• Subcellular Location：
• Cell membrane ; Lipid-anchor ; Cytoplasmic side .

• Expression：
• Brain,

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