Epac Polyclonal Antibody

    • Catalog No.:YT1571
    • Applications:WB;ELISA
    • Reactivity:Human;Mouse;Rat
      • Target:
      • Epac
      • Fields:
      • >>Rap1 signaling pathway;>>cAMP signaling pathway;>>Phospholipase D signaling pathway;>>Adrenergic signaling in cardiomyocytes;>>Leukocyte transendothelial migration;>>Long-term potentiation;>>Serotonergic synapse
      • Gene Name:
      • RAPGEF3
      • Protein Name:
      • Rap guanine nucleotide exchange factor 3
      • Human Swiss Prot No:
      • O95398
      • Mouse Swiss Prot No:
      • Q8VCC8
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human RAPGEF3. AA range:712-761
      • Specificity:
      • Epac Polyclonal Antibody detects endogenous levels of Epac protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • RAPGEF3;CGEF1;EPAC;EPAC1;Rap guanine nucleotide exchange factor 3;Exchange factor directly activated by cAMP 1;Exchange protein directly activated by cAMP 1;EPAC 1;Rap1 guanine-nucleotide-exchange factor directly activated by cAMP;
      • Observed Band(KD):
      • 100kD
      • Background:
      • caution:It is uncertain whether Met-1 or Met-43 is the initiator.,domain:The DEP domain is involved in membrane localization independent from regulation by cAMP.,function:Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 DEP domain.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,tissue specificity:Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.,
      • Function:
      • caution:It is uncertain whether Met-1 or Met-43 is the initiator.,domain:The DEP domain is involved in membrane localization independent from regulation by cAMP.,function:Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 DEP domain.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,tissue specificity:Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.,
      • Subcellular Location:
      • Endomembrane system .
      • Expression:
      • Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.
      • Products Images
      • Western blot analysis of the lysates from HeLa cells using RAPGEF3 antibody.