Desmin Polyclonal Antibody

    • Catalog No.:YT1326
    • Applications:WB,IHC-p,IF,ELISA
    • Reactivity:Human,Mouse,Rat
      • Gene Name:
      • DES
      • Protein Name:
      • Desmin
      • Human Gene Id:
      • 1674
      • Human Swiss Prot No:
      • P17661
      • Mouse Swiss Prot No:
      • P31001
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human Desmin. AA range:421-470
      • Specificity:
      • Desmin Polyclonal Antibody detects endogenous levels of Desmin protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Rabbit
      • Dilution:
      • Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • DES; Desmin
      • MolecularWeight(Da):
      • 53536
      • Observed Band(KD):
      • 55
      • Background:
      • desmin(DES) Homo sapiens This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008],
      • Function:
      • disease:Defects in DES are the cause of cardiomyopathy dilated type 1I (CMD1I) [MIM:604765]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,disease:Defects in DES are the cause of desmin-related cardio-skeletal myopathy (CSM) [MIM:601419]; also known as desmin-related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells. A desmin-related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM).,disease:Defects in DES are the cause of neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome) [MIM:181400].
      • Subcellular Location:
      • cytosol,intermediate filament,fascia adherens,intercalated disc,Z disc,neuromuscular junction,sarcolemma,intermediate filament cytoskeleton,extracellular exosome,
      • Expression:
      • Muscle,Skeletal muscle,
      • Products Images
      • Western Blot analysis of various cells using Desmin Polyclonal Antibody diluted at 1:2000
      • Western Blot analysis of VEC cells using Desmin Polyclonal Antibody diluted at 1:2000
      • The picture was kindly provided by our customer
      • Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue, using Desmin Antibody. The picture on the right is blocked with the synthesized peptide.
      • Western blot analysis of lysates from K562 cells, using Desmin Antibody. The lane on the right is blocked with the synthesized peptide.