• Target：
• Citron

• Gene Name：
• CIT

• Protein Name：
• Citron Rho-interacting kinase

• Human Gene Id：
• 11113

• Human Swiss Prot No：
• O14578

• Mouse Swiss Prot No：
• P49025

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CTRO. AA range:1011-1060

• Specificity：
• Citron Polyclonal Antibody detects endogenous levels of Citron protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CIT;CRIK;KIAA0949;STK21;Citron Rho-interacting kinase;CRIK;Serine/threonine-protein kinase 21

• Molecular Weight(Da)：
• 231kD

• Background：
• This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],

• Function：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Required for KIF14 localization to the central spindle and midbody. May play a role in cytokinesis. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Plays an important role in the regulation of cytokinesis and the development of the central nervous system.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 CNH domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,sim

• Subcellular Location：
• Cytoplasm .

• Expression：
• Brain,Epithelium,

High expression of citron kinase predicts poor prognosis of prostate cancer. Oncology Letters 2020 Jan 07 IHC Human prostate cancer (PCa) tissue

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