ARHGAP23 Polyclonal Antibody

    • Catalog No.:YT0319
    • Applications:IHC;IF;WB;ELISA
    • Reactivity:Human;Rat;Mouse;
      • Target:
      • ARHGAP23
      • Gene Name:
      • ARHGAP23
      • Protein Name:
      • Rho GTPase-activating protein 23
      • Human Swiss Prot No:
      • Q9P227
      • Mouse Swiss Prot No:
      • Q69ZH9
      • Immunogen:
      • Synthesized peptide derived from ARHGAP23 . at AA range: 470-550
      • Specificity:
      • ARHGAP23 Polyclonal Antibody detects endogenous levels of ARHGAP23 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • ARHGAP23;KIAA1501;Rho GTPase-activating protein 23;Rho-type GTPase-activating protein 23
      • Molecular Weight(Da):
      • 162kD
      • Background:
      • The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008],
      • Function:
      • function:GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 Rho-GAP domain.,tissue specificity:Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor, salivary gland tumor, head and neck tumor.,
      • Subcellular Location:
      • cytosol,extracellular exosome,
      • Expression:
      • Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor, salivary gland tumor, head and neck tumor.
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded human Gastric adenocarcinoma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).