ABCC12 Polyclonal Antibody

    • Catalog No.:YT0047
    • Applications:WB;ELISA
    • Reactivity:Human;Rat;Mouse;
      • Target:
      • ABCC12
      • Fields:
      • >>ABC transporters
      • Gene Name:
      • ABCC12
      • Protein Name:
      • Multidrug resistance-associated protein 9
      • Human Swiss Prot No:
      • Q96J65
      • Mouse Swiss Prot No:
      • Q80WJ6
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human MRP9. AA range:691-740
      • Specificity:
      • ABCC12 Polyclonal Antibody detects endogenous levels of ABCC12 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • ABCC12;MRP9;Multidrug resistance-associated protein 9;ATP-binding cassette sub-family C member 12
      • Observed Band(KD):
      • 170kD
      • Background:
      • This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008],
      • Function:
      • developmental stage:Expressed in fetal tissues.,function:Probable transporter.,similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily.,similarity:Contains 2 ABC transmembrane type-1 domains.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Expressed in testis (at protein level). Widely expressed at low level. Isoform 5 is specifically expressed in brain, testis and breast cancer cells.,
      • Subcellular Location:
      • Endoplasmic reticulum membrane ; Multi-pass membrane protein .
      • Expression:
      • Expressed in testis (at protein level). Widely expressed at low level (PubMed:11483364, PubMed:11688999, PubMed:12011458, PubMed:17472575). Isoform 5 is specifically expressed in brain, testis and breast cancer cells (PubMed:11483364, PubMed:11688999, PubMed:12011458).
      • Products Images
      • Western Blot analysis of various cells using ABCC12 Polyclonal Antibody diluted at 1:500
      • Western blot analysis of lysates from 293, HepG2, and HUVEC cells, using MRP9 Antibody. The lane on the right is blocked with the synthesized peptide.