• Target：
• A1Up

• Fields：
• >>Protein processing in endoplasmic reticulum;>>Amyotrophic lateral sclerosis

• Gene Name：
• UBQLN4

• Protein Name：
• Ubiquilin-4

• Human Gene Id：
• 56893

• Human Swiss Prot No：
• Q9NRR5

• Mouse Gene Id：
• 94232

• Mouse Swiss Prot No：
• Q99NB8

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human UBQLN4. AA range:201-250

• Specificity：
• A1Up Polyclonal Antibody detects endogenous levels of A1Up protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• UBQLN4;C1orf6;CIP75;UBIN;Ubiquilin-4;Ataxin-1 interacting ubiquitin-like protein;A1Up;Ataxin-1 ubiquitin-like-interacting protein A1U;Connexin43-interacting protein of 75 kDa;CIP75

• Observed Band(KD)：
• 54kD

• Background：
• PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 UBA domain.,similarity:Contains 1 ubiquitin-like domain.,subcellular location:May associate with the endoplasmic reticulum.,subunit:Homodimer. Binds SCA1. Binds signal sequences of proteins that are targeted to the endoplasmic reticulum.,tissue specificity:Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.,

• Function：
• PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 UBA domain.,similarity:Contains 1 ubiquitin-like domain.,subcellular location:May associate with the endoplasmic reticulum.,subunit:Homodimer. Binds SCA1. Binds signal sequences of proteins that are targeted to the endoplasmic reticulum.,tissue specificity:Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.,

• Subcellular Location：
• Nucleus . Cytoplasm . Chromosome . Endoplasmic reticulum . Cytoplasm, perinuclear region . Cytoplasmic vesicle, autophagosome . Colocalizes with the proteasome, both in nucleus and cytoplasm (PubMed:15280365). Exported from the nucleus following interaction with DESI1/POST (PubMed:29666234). In response to DNA damage and phosphorylation at Ser-318 by ATM, localizes to the nucleus and is recruited to sites of DNA damage (PubMed:30612738). .

• Expression：
• Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.

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