CARD11 (Phospho Ser652) rabbit pAb

  • Catalog No.:YP1286
  • Applications:WB
  • Reactivity:Human;Mouse;Rat
    • Target:
    • CARD11
    • Fields:
    • >>NF-kappa B signaling pathway;>>T cell receptor signaling pathway;>>B cell receptor signaling pathway
    • Gene Name:
    • CARD11 CARMA1
    • Protein Name:
    • CARD11 (Ser652)
    • Human Swiss Prot No:
    • Q9BXL7
    • Mouse Swiss Prot No:
    • Q8CIS0
    • Immunogen:
    • Synthesized phosho peptide around human CARD11 (Ser652)
    • Specificity:
    • This antibody detects endogenous levels of Human Mouse Rat CARD11 (phospho-Ser652)
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Polyclonal, Rabbit,IgG
    • Dilution:
    • WB 1:1000-2000
    • Purification:
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name:
    • Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 1) (Carma 1)
    • Observed Band(KD):
    • 130kD
    • Background:
    • The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008],
    • Function:
    • caution:Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.,function:Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.,similarity:Contains 1 CARD domain.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 PDZ (DHR) domain.,subunit:CARD11 and BCL10 bind to each other by CARD-CARD interaction.,tissue specificity:Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells.,
    • Subcellular Location:
    • Cytoplasm . Membrane raft . Colocalized with DPP4 in membrane rafts. .
    • Expression:
    • Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells.