Nuclear Receptor NR4A1 (Phospho Ser351) Antibody

    • Catalog No.:YP1248
    • Applications:WB;ELISA
    • Reactivity:Human;Mouse;Rat
      • Target:
      • Nur77
      • Fields:
      • >>MAPK signaling pathway;>>PI3K-Akt signaling pathway;>>Aldosterone synthesis and secretion;>>Cortisol synthesis and secretion;>>Cushing syndrome
      • Gene Name:
      • NR4A1 GFRP1 HMR NAK1
      • Protein Name:
      • Nuclear Receptor NR4A1 (Phospho-Ser351)
      • Human Gene Id:
      • 3164
      • Human Swiss Prot No:
      • P22736
      • Immunogen:
      • Synthesized pospho peptide derived from human Nuclear Receptor NR4A1 (Phospho-Ser351)
      • Specificity:
      • This antibody detects endogenous pospho levels of human Nuclear Receptor NR4A1 (Phospho-Ser351)
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500-2000, ELISA(peptide)1:5000-20000
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • Nuclear receptor subfamily 4 group A member 1 (Early response protein NAK1;Nuclear hormone receptor NUR/77;Nur77;Orphan nuclear receptor HMR;Orphan nuclear receptor TR3;ST-59;Testicular receptor 3)
      • Observed Band(KD):
      • 77kD
      • Background:
      • This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],
      • Function:
      • function:Orphan nuclear receptor.,induction:By growth-stimulating agents.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR4 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with GADD45GIP1.,tissue specificity:Fetal muscle and adult liver, brain and thyroid.,
      • Subcellular Location:
      • Nucleus . Cytoplasm . Mitochondrion . Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). .
      • Expression:
      • Fetal muscle and adult liver, brain and thyroid.
      • Products Images
      • Western blot analysis of various lysates, primary antibody was diluted at 1:1000, 4° over night, secondary antibody(cat: RS23920)was diluted at 1:10000, 37° 1hour.