IGF-IR (phospho Tyr1165/Y1166) Polyclonal Antibody

    • Catalog No.:YP0139
    • Applications:WB,ELISA
    • Reactivity:Human,Mouse,Rat,Monkey
    • Description
    • Gene Name:
    • IGF1R
    • Protein Name:
    • Insulin-like growth factor 1 receptor
    • Human Gene Id:
    • 3480
    • Human Swiss Prot No:
    • P08069
    • Mouse Swiss Prot No:
    • Q60751
    • Immunogen:
    • The antiserum was produced against synthesized peptide derived from human IGF1R around the phosphorylation site of Tyr1165/Tyr1166. AA range:1131-1180
    • Specificity:
    • Phospho-IGF-IR (Y1165/Y1166) Polyclonal Antibody detects endogenous levels of IGF-IR protein only when phosphorylated at Y1165/Y1166.
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Rabbit
    • Dilution:
    • Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
    • Purification:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Other Name:
    • IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221
    • MolecularWeight(Da):
    • 154793
    • Observed Band(KD):
    • 156
    • Background:
    • Insulin like growth factor 1 receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for IGF1R.
    • Function:
    • cell morphogenesis, cell morphogenesis involved in differentiation, reproductive developmental proce
    • Products Images
    • Western Blot analysis of various cells using Phospho-IGF-IR (Y1165/Y1166) Polyclonal Antibody diluted at 1:500
    • Western Blot analysis of COS7 cells using Phospho-IGF-IR (Y1165/Y1166) Polyclonal Antibody diluted at 1:500
    • Western blot analysis of lysates from 293 cells treated with Insulin, using IGF1R (Phospho-Tyr1165/Tyr1166) Antibody. The lane on the right is blocked with the phospho peptide.