BRCA1 (phospho Ser1524) Polyclonal Antibody

    • Catalog No.:YP0039
    • Applications:WB,IHC-p,IF(paraffin section),ELISA
    • Reactivity:Human,Rat,Mouse,
      • Gene Name:
      • BRCA1
      • Protein Name:
      • Breast cancer type 1 susceptibility protein
      • Human Gene Id:
      • 672
      • Human Swiss Prot No:
      • P38398
      • Mouse Swiss Prot No:
      • P48754
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human BRCA1 around the phosphorylation site of Ser1524. AA range:1491-1540
      • Specificity:
      • Phospho-BRCA1 (S1524) Polyclonal Antibody detects endogenous levels of BRCA1 protein only when phosphorylated at S1524.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal Rabbit
      • Dilution:
      • Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53
      • MolecularWeight(Da):
      • 207721
      • Background:
      • BRCA1, DNA repair associated(BRCA1) Homo sapiens This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript varian
      • Function:
      • disease:Defects in BRCA1 are a cause of genetic susceptibility to breast cancer (BC) [MIM:113705, 114480]. BC is an extremely common malignancy, affecting one in eight women during their lifetime. A positive family history has been identified as major contributor to risk of development of the disease, and this link is striking for early-onset breast cancer. Mutations in BRCA1 are thought to be responsible for 45% of inherited breast cancer. Moreover, BRCA1 carriers have a 4-fold increased risk of colon cancer, whereas male carriers face a 3-fold increased risk of prostate cancer. Cells lacking BRCA1 show defects in DNA repair by homologous recombination.,disease:Defects in BRCA1 are a cause of genetic susceptibility to ovarian cancer [MIM:113705].,disease:Defects in BRCA1 are a cause of susceptibility to familial breast-ovarian cancer type 1 (BROVCA1) [MIM:604370]. Mutations in BRCA1 are
      • Subcellular Location:
      • ubiquitin ligase complex,condensed nuclear chromosome,lateral element,nucleus,nucleoplasm,chromosome,cytoplasm,plasma membrane,gamma-tubulin ring complex,integral component of membrane,intracellular ribonucleoprotein complex,
      • Expression:
      • Bladder,Blood,Epithelium,Mammary gland,PCR rescued clones,Peripheral Nervou
      • Products Images
      • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using BRCA1 (Phospho-Ser1524) Antibody. The picture on the right is blocked with the phospho peptide.