• Target：
• BEST2

• Fields：
• >>Salivary secretion

• Gene Name：
• BEST2

• Protein Name：
• Bestrophin-2

• Human Gene Id：
• 54831

• Human Swiss Prot No：
• Q8NFU1

• Mouse Swiss Prot No：
• Q8BGM5

• Immunogen：
• Synthetic Peptide of BEST2

• Specificity：
• The antibody detects endogenous BEST2 protein.

• Formulation：
• PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-1000 IHC 1:200-500. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Bestrophin-2;Vitelliform macular dystrophy 2-like protein 1

• Observed Band(KD)：
• 50kD

• Background：
• This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon. [provided by RefSeq, Jul 2008],

• Function：
• function:Forms calcium-sensitive chloride channels. May conduct other physiologically significant anions such as bicarbonate.,similarity:Belongs to the bestrophin family.,tissue specificity:Mainly confined to the retinal pigment epithelium and colon.,

• Subcellular Location：
• Cell membrane; Multi-pass membrane protein.

• Expression：
• Mainly confined to the retinal pigment epithelium and colon.

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