GABA Transporter 1 Polyclonal Antibody

    • Catalog No.:YN5590
    • Applications:WB;IHC;IF
    • Reactivity:Human;Rat;Mouse
      • Target:
      • GABA T-1
      • Fields:
      • >>Synaptic vesicle cycle;>>GABAergic synapse
      • Gene Name:
      • SLC6A1
      • Protein Name:
      • Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1)
      • Human Gene Id:
      • 6529
      • Human Swiss Prot No:
      • P30531
      • Mouse Swiss Prot No:
      • P31648
      • Immunogen:
      • Synthetic Peptide of GABA Transporter 1 AA range: 329-379
      • Specificity:
      • GABA Transporter 1 protein(A230) detects endogenous levels of GABA Transporter 1
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:1000-2000, IHC 1:100-200. IF 1:50-200
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • SLC6A1;GABATR;GABT1;GAT1;Sodium- and chloride-dependent GABA transporter 1;GAT-1;Solute carrier family 6 member 1
      • Observed Band(KD):
      • 67kD
      • Background:
      • The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009],
      • Function:
      • domain:The PDZ domain-binding motif is involved in the interaction with MPP5.,function:Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.,miscellaneous:This protein is the target of psychomotor stimulants such as amphetamines or cocaine.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,subcellular location:Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons.,subunit:Interacts with MPP5.,
      • Subcellular Location:
      • Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Cell junction, synapse, presynapse . Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity). .
      • Expression:
      • Brain,
      • Products Images
      • Western blot analysis of 1) Mouse Brain Tissue, 2)Rat Brain Tissue with GABA Transporter 1 Rabbit pAb diluted at 1:2,000.
      • Immunohistochemical analysis of paraffin-embedded Rat BrainTissue using GABA Transporter 1 Rabbit pAb diluted at 1:200.
      • Immunohistochemical analysis of paraffin-embedded Mouse BrainTissue using GABA Transporter 1 Rabbit pAb diluted at 1:200.