GAP43 Polyclonal Antibody
- Catalog No.:YN5586
- Applications:WB
- Reactivity:Human;Mouse;Rat
- Target:
- GAP-43
- Gene Name:
- GAP43
- Protein Name:
- Neuromodulin
- Human Gene Id:
- 2596
- Human Swiss Prot No:
- P17677
- Mouse Gene Id:
- 14432
- Mouse Swiss Prot No:
- P06837
- Rat Gene Id:
- 29423
- Rat Swiss Prot No:
- P07936
- Immunogen:
- Recombinant Protein of Neuromodulin
- Specificity:
- The antibody detects endogenous GAP43 protein.
- Formulation:
- PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:1000-3000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- GAP43;Neuromodulin;Axonal membrane protein GAP-43;Growth-associated protein 43;Neural phosphoprotein B-50;pp46
- Observed Band(KD):
- 38,43kD
- Background:
- The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
- Function:
- function:This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons.,online information:Gap-43 entry,PTM:Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.,similarity:Belongs to the neuromodulin family.,similarity:Contains 1 IQ domain.,subcellular location:Cytoplasmic surface of growth cone and synaptic plasma membranes.,subunit:Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.,
- Subcellular Location:
- Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, growth cone membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . Cell projection, filopodium membrane ; Peripheral membrane protein . Perikaryon . Cell projection, dendrite . Cell projection, axon . Cytoplasm . Cytoplasmic surface of growth cone and synaptic plasma membranes. .
- Expression:
- Alzheimer cortex,Brain,Subthalamic nucleus,
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- Products Images
- Western blot analysis of 1) Hela, 2) Mouse Brain, 3) Rat Brain tissue, diluted at 1:3000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000