DVL1 Polyclonal Antibody

  • Catalog No.:YN2890
  • Applications:WB,ELISA
  • Reactivity:Human,Mouse,Rat
    • Gene Name:
    • DVL1
    • Protein Name:
    • Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
    • Human Gene Id:
    • 1855
    • Human Swiss Prot No:
    • O14640
    • Mouse Swiss Prot No:
    • P51141
    • Immunogen:
    • Synthesized peptide derived from part region of human protein
    • Specificity:
    • DVL1 Polyclonal Antibody detects endogenous levels of protein.
    • Formulation:
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source:
    • Rabbit
    • Dilution:
    • WB 1:500-2000 ELISA 1:5000-20000
    • Purification:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Observed Band(KD):
    • 76
    • Background:
    • dishevelled segment polarity protein 1(DVL1) Homo sapiens DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008],
    • Function:
    • disease:May be partly responsible for CATCH22 syndromes. This denomination includes developmental defects which associate cardiac defect, abnormal facies, thymic hypoplasia, cleft palate, hypocalcemia, and chromosome 22 deletions.,function:May play a role in the signal transduction pathway mediated by multiple Wnt genes.,PTM:Ubiquitinated, leading to its subsequent degradation by the ubiquitin-proteasome. The interaction with INVS is required for ubiquitination.,similarity:Belongs to the DSH family.,similarity:Contains 1 DEP domain.,similarity:Contains 1 DIX domain.,similarity:Contains 1 PDZ (DHR) domain.,subunit:Interacts with CXXC4. Interacts (via PDZ domain) with NXN (By similarity). Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE.,tissue specificity:Expressed in the thymus and, at high levels, in the heart
    • Subcellular Location:
    • intracellular,cytosol,microtubule,plasma membrane,postsynaptic density,cytoplasmic, membrane-bounded vesicle,lateral plasma membrane,clathrin-coated vesicle,axon,growth cone,cytoplasmic vesicle,neuron projection,
    • Expression:
    • Brain,Eye,Peripheral Nervous System,Sympathetic ganglion,Testis,