SPRE1 Polyclonal Antibody

  • Catalog No.:YN2399
  • Applications:WB;ELISA
  • Reactivity:Human;Mouse
    • Target:
    • SPRE1
    • Gene Name:
    • SPRED1
    • Protein Name:
    • Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1)
    • Human Swiss Prot No:
    • Q7Z699
    • Mouse Swiss Prot No:
    • Q924S8
    • Immunogen:
    • Synthesized peptide derived from human protein . at AA range: 210-290
    • Specificity:
    • SPRE1 Polyclonal Antibody detects endogenous levels of protein.
    • Formulation:
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source:
    • Polyclonal, Rabbit,IgG
    • Dilution:
    • WB 1:500-2000 ELISA 1:5000-20000
    • Purification:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Observed Band(KD):
    • 48kD
    • Background:
    • The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008],
    • Function:
    • disease:Defects in SPRED1 are the cause of neurofibromatosis type 1-like syndrome (NFLS) [MIM:611431]. Neurofibromatosis type 1 (NF1) is one of the most frequent autosomal dominant diseases. It belongs to the group of disorders known as the 'neuro-cardio-facial-cutaneous' syndromes, present with a variable degree of cognitive impairment, facial dysmorphism, congenital heart defects and skin abnormalities. NFLS is a form of these disorders with autosomal dominant trait consisting of multiple cafe-au-lait spots, axillary freckling, macrocephaly and a Noonan-like dysmorphy in some individuals.,function:Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow.,PTM:Phosphorylated on tyrosine.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Contains 1 KBD domain.,similarity:Contains
    • Subcellular Location:
    • Cell membrane ; Peripheral membrane protein . Membrane, caveola ; Peripheral membrane protein . Nucleus . Localized in cholesterol-rich membrane raft/caveola fractions.
    • Expression:
    • Weakly expressed in embryonic cell line HEK293.