PRLR Polyclonal Antibody
- Catalog No.:YN2369
- Applications:WB;ELISA
- Reactivity:Human
- Target:
- PRLR
- Fields:
- >>Cytokine-cytokine receptor interaction;>>Neuroactive ligand-receptor interaction;>>PI3K-Akt signaling pathway;>>JAK-STAT signaling pathway;>>Prolactin signaling pathway
- Gene Name:
- PRLR
- Protein Name:
- Prolactin receptor (PRL-R)
- Human Gene Id:
- 5618
- Human Swiss Prot No:
- P16471
- Mouse Swiss Prot No:
- Q08501
- Rat Swiss Prot No:
- P05710
- Immunogen:
- Synthesized peptide derived from human protein . at AA range: 80-160
- Specificity:
- PRLR Polyclonal Antibody detects endogenous levels of protein.
- Formulation:
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000 ELISA 1:5000-20000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Observed Band(KD):
- 68kD
- Background:
- This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011],
- Function:
- domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoforms 4 and 6 are unable to transduce prolactin signaling.,similarity:Belongs to the type I cytokine receptor family. Type 1 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subcellular location:Isoform 7.,subunit:Interacts with SMARCA1. Interacts with GH1.,tissue specificity:Expressed in breast, placenta, kidney, liver and pancreas.,
- Subcellular Location:
- Membrane ; Single-pass type I membrane protein .; [Isoform 7]: Secreted.
- Expression:
- Expressed in breast, placenta, kidney, liver and pancreas.
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