PRLR Polyclonal Antibody

  • Catalog No.:YN2369
  • Applications:WB;ELISA
  • Reactivity:Human
    • Target:
    • PRLR
    • Fields:
    • >>Cytokine-cytokine receptor interaction;>>Neuroactive ligand-receptor interaction;>>PI3K-Akt signaling pathway;>>JAK-STAT signaling pathway;>>Prolactin signaling pathway
    • Gene Name:
    • PRLR
    • Protein Name:
    • Prolactin receptor (PRL-R)
    • Human Gene Id:
    • 5618
    • Human Swiss Prot No:
    • P16471
    • Mouse Swiss Prot No:
    • Q08501
    • Immunogen:
    • Synthesized peptide derived from human protein . at AA range: 80-160
    • Specificity:
    • PRLR Polyclonal Antibody detects endogenous levels of protein.
    • Formulation:
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source:
    • Polyclonal, Rabbit,IgG
    • Dilution:
    • WB 1:500-2000 ELISA 1:5000-20000
    • Purification:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Observed Band(KD):
    • 68kD
    • Background:
    • This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011],
    • Function:
    • domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoforms 4 and 6 are unable to transduce prolactin signaling.,similarity:Belongs to the type I cytokine receptor family. Type 1 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subcellular location:Isoform 7.,subunit:Interacts with SMARCA1. Interacts with GH1.,tissue specificity:Expressed in breast, placenta, kidney, liver and pancreas.,
    • Subcellular Location:
    • Membrane ; Single-pass type I membrane protein .; [Isoform 7]: Secreted.
    • Expression:
    • Expressed in breast, placenta, kidney, liver and pancreas.