• Target：
• IGF-2

• Fields：
• >>MAPK signaling pathway;>>Ras signaling pathway;>>PI3K-Akt signaling pathway;>>Pathways in cancer;>>Proteoglycans in cancer;>>Hepatocellular carcinoma

• Gene Name：
• IGF2 PP1446

• Protein Name：
• Insulin-like growth factor II (IGF-II) (Somatomedin-A) [Cleaved into: Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin]

• Human Gene Id：
• 3481

• Human Swiss Prot No：
• P01344

• Mouse Swiss Prot No：
• P09535

• Rat Swiss Prot No：
• P01346

• Immunogen：
• Synthesized peptide derived from part region of human protein AA range: 25-40

• Specificity：
• IGF2 Polyclonal Antibody detects endogenous levels of protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000 ELISA 1:5000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Observed Band(KD)：
• 10 or 19 Kd

• Background：
• This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010],

• Function：
• disease:Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].,function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.,function:Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.,function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.,mass spectrometry: PubMed:12586351; PubMed:15359740,online information:Clinical information on Eli Lilly insu

• Subcellular Location：
• Secreted .

• Expression：
• Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas.

Liver Expression of IGF2 and Related Proteins in ZBED6 Gene-Edited Pig by RNA-Seq. Animals Animals-Basel. 2020 Nov;10(11):2184 WB Pig Liver,spleen,heart,semitendinosus,semimembranosus

Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Jinyuan Yan WB Human 1:500 SHSY5Y cell

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