M3K14 Polyclonal Antibody

  • Catalog No.:YN1594
  • Applications:WB;ELISA
  • Reactivity:Human;Rat;Mouse;
    • Target:
    • M3K14
    • Fields:
    • >>MAPK signaling pathway;>>NF-kappa B signaling pathway;>>Apoptosis;>>Osteoclast differentiation;>>C-type lectin receptor signaling pathway;>>T cell receptor signaling pathway;>>TNF signaling pathway;>>Intestinal immune network for IgA production;>>Alcoholic liver disease;>>Epithelial cell signaling in Helicobacter pylori infection;>>Human T-cell leukemia virus 1 infection;>>Epstein-Barr virus infection;>>Chemical carcinogenesis - reactive oxygen species
    • Gene Name:
    • MAP3K14 NIK
    • Protein Name:
    • Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)
    • Human Gene Id:
    • 9020
    • Human Swiss Prot No:
    • Q99558
    • Mouse Swiss Prot No:
    • Q9WUL6
    • Immunogen:
    • Synthesized peptide derived from human protein . at AA range: 90-170
    • Specificity:
    • M3K14 Polyclonal Antibody detects endogenous levels of protein.
    • Formulation:
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • Source:
    • Polyclonal, Rabbit,IgG
    • Dilution:
    • WB 1:500-2000 ELISA 1:5000-20000
    • Purification:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Observed Band(KD):
    • 104kD
    • Background:
    • This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008],
    • Function:
    • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Induces the processing of NF-kappa-B 2/P100. Could act in a receptor-selective manner.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds to TRAF2, TRAF5, TRAF6, IKKA and NF-kappa-B 2/P100 (By similarity). Interacts with PELI3. Interacts with NIBP; the interaction is direct.,tissue specificity:Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.,
    • Subcellular Location:
    • Cytoplasm.
    • Expression:
    • Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.