RAC3 Polyclonal Antibody

    • Catalog No.:YN1163
    • Applications:WB,ELISA
    • Reactivity:Human,Mouse
      • Gene Name:
      • RAC3
      • Protein Name:
      • Ras-related C3 botulinum toxin substrate 3 (p21-Rac3)
      • Human Gene Id:
      • 5881
      • Human Swiss Prot No:
      • P60763
      • Mouse Swiss Prot No:
      • P60764
      • Immunogen:
      • Synthesized peptide derived from human protein . at AA range: 80-160
      • Specificity:
      • RAC3 Polyclonal Antibody detects endogenous levels of protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
      • Source:
      • Rabbit
      • Dilution:
      • WB 1:500-2000 ELISA 1:5000-20000
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Observed Band(KD):
      • 21
      • Background:
      • ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)(RAC3) Homo sapiens The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
      • Function:
      • function:Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.,induction:Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation.,similarity:Belongs to the small GTPase superfamily. Rho family.,subcellular location:Membrane-associated when activated. Co-localizes with NRBP to endomembranes and at the cell periphery in lamellipodia.,subunit:Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D.,tissue specificity:Highest levels in brain, also detected in heart, placenta and pancreas.,
      • Subcellular Location:
      • intracellular,cytosol,plasma membrane,endomembrane system,lamellipodium,growth cone,filamentous actin,neuron projection,neuronal cell body,perinuclear region of cytoplasm,extr
      • Expression:
      • Brain,
      • Products Images
      • Western blot analysis of lysates from A431 cells, primary antibody was diluted at 1:1000, 4°over night