EDEM3 Polyclonal Antibody

    • Catalog No.:YN0703
    • Applications:WB;ELISA
    • Reactivity:Human;Mouse
      • Target:
      • EDEM3
      • Fields:
      • >>Protein processing in endoplasmic reticulum
      • Gene Name:
      • EDEM3 C1orf22
      • Protein Name:
      • ER degradation-enhancing alpha-mannosidase-like 3
      • Human Swiss Prot No:
      • Q9BZQ6
      • Mouse Swiss Prot No:
      • Q2HXL6
      • Immunogen:
      • Synthesized peptide derived from part region of human protein
      • Specificity:
      • EDEM3 Polyclonal Antibody detects endogenous levels of protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500-2000 ELISA 1:5000-20000
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Observed Band(KD):
      • 102kD
      • Background:
      • Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008],
      • Function:
      • domain:Contains a protease-associated domain (PA) of unknown function.,function:Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes. This process depends on mannose-trimming from the N-glycans. Seems to have alpha 1,2-mannosidase activity.,PTM:N-glycosylated.,similarity:Belongs to the glycosyl hydrolase 47 family.,similarity:Contains 1 PA (protease associated) domain.,
      • Subcellular Location:
      • Endoplasmic reticulum lumen .
      • Expression:
      • Brain,Liver,Lung,Placenta,Testis,Whole embr
      • Products Images
      • Western Blot analysis of Hela lysis, using primary antibody at 1:1000 dilution. Secondary antibody(catalog#:RS23920) was diluted at 1:10000