EDEM3 Polyclonal Antibody
- Catalog No.:YN0703
- Applications:WB;ELISA
- Reactivity:Human;Mouse
- Target:
- EDEM3
- Fields:
- >>Protein processing in endoplasmic reticulum
- Gene Name:
- EDEM3 C1orf22
- Protein Name:
- ER degradation-enhancing alpha-mannosidase-like 3
- Human Gene Id:
- 80267
- Human Swiss Prot No:
- Q9BZQ6
- Mouse Swiss Prot No:
- Q2HXL6
- Immunogen:
- Synthesized peptide derived from part region of human protein
- Specificity:
- EDEM3 Polyclonal Antibody detects endogenous levels of protein.
- Formulation:
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000 ELISA 1:5000-20000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Observed Band(KD):
- 102kD
- Background:
- Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008],
- Function:
- domain:Contains a protease-associated domain (PA) of unknown function.,function:Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes. This process depends on mannose-trimming from the N-glycans. Seems to have alpha 1,2-mannosidase activity.,PTM:N-glycosylated.,similarity:Belongs to the glycosyl hydrolase 47 family.,similarity:Contains 1 PA (protease associated) domain.,
- Subcellular Location:
- Endoplasmic reticulum lumen .
- Expression:
- Brain,Liver,Lung,Placenta,Testis,Whole embr
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- Antibody-FAQs
- Products Images
- Western Blot analysis of Hela lysis, using primary antibody at 1:1000 dilution. Secondary antibody(catalog#:RS23920) was diluted at 1:10000