p120 catenin mouse mAb(ABT-p120)

    • Catalog No.:YM6752
    • Applications:IHC-p,IF(paraffin section)
    • Reactivity:Human
      • Gene Name:
      • CTNND1 KIAA0384
      • Protein Name:
      • p120 catenin
      • Human Gene Id:
      • 1500
      • Human Swiss Prot No:
      • O60716
      • Immunogen:
      • Synthesized peptide derived from human p120 catenin
      • Specificity:
      • This antibody detects endogenous levels of human p120 catenin. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH9.0 was highly recommended as antigen repair method in paraffin section
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Mouse
      • Dilution:
      • IF(paraffin section) 1:50-200 IHC-p 1:300-500,
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))
      • Background:
      • catenin delta 1(CTNND1) Homo sapiens This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010],
      • Function:
      • alternative products:Experimental confirmation may be lacking for some isoforms,disease:May contribute to cell malignancy. Complete loss of expression was observed in approximately 10% of invasive ductal breast carcinomas investigated.,domain:A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.,function:Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.,induction:Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound clo
      • Subcellular Location:
      • Membranous, Cytoplasmic
      • Expression:
      • Brain,Epithelium,Fetal kidney,Placenta,Testis,
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded Colon carcinoma. 1, Antibody was diluted at 1:200(4° overnight). 2, TRIS-EDTA of pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
      • Immunohistochemical analysis of paraffin-embedded Invasive ductal breast carcinoma. 1, Antibody was diluted at 1:200(4° overnight). 2, TRIS-EDTA of pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).