TGF β Receptor II (ABT-TGFR2) mouse mAb

    • Catalog No.:YM6672
    • Applications:IHC-p
    • Reactivity:Human
    • Description
    • Gene Name:
    • TGFBR2
    • Protein Name:
    • TGF β Receptor II
    • Human Gene Id:
    • 7048
    • Human Swiss Prot No:
    • P37173
    • Immunogen:
    • Synthesized peptide derived from human TGF β Receptor II
    • Specificity:
    • This antibody detects endogenous levels of human TGF β Receptor II
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Mouse/IgG1, Kappa
    • Dilution:
    • IHC-p 1:100-500
    • Purification:
    • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Background:
    • TGFBR2 encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The TGF-beta receptor type-2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
    • Function:
    • skeletal system development, angiogenesis, blood vessel development, patterning of blood vessels, vasculogenesis,morphogenesis of a branching structure, myeloid dendritic cell activation, cell activation, vasculature development,positive regulation of mesenchymal cell proliferation, myeloid leukocyte activation, immune system development,leukocyte differentiation, myeloid leukocyte differentiation, regulation of tolerance induction, positive regulation of tolerance induction, regulation of tolerance induction to self antigen, positive regulation of tolerance induction to self antigen, regulation of B cell tolerance induction, positive regulation of B cell tolerance induction, regulation of T cell tolerance induction, positive regulation of T cell tolerance induction, positive regulation of immune system process,regulation of leukocyte activation, positive regulation of leukocyte activati
    • Products Images
    • Immunohistochemical analysis of paraffin-embedded Colon carcinoma-high magnification. 1, Antibody was diluted at 1:200(4°,overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
    • Immunohistochemical analysis of paraffin-embedded Colon carcinoma. 1, Antibody was diluted at 1:200(4°,overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).