Tissue Inhibitor of Metalloproteinases 1(PT2236) mouse mAb

    • Catalog No.:YM6655
    • Applications:IHC-p
    • Reactivity:Human
    • Description
    • Gene Name:
    • TIMP1 CLGI TIMP
    • Protein Name:
    • Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1)
    • Human Gene Id:
    • 7076
    • Human Swiss Prot No:
    • P01033
    • Immunogen:
    • Synthesized peptide derived from human Tissue Inhibitor of Metalloproteinases 1(TIMP1)
    • Specificity:
    • This antibody detects endogenous levels of human Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of m
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Mouse/IgG1, Kappa
    • Dilution:
    • IHC-p 1:100-500
    • Purification:
    • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Background:
    • TIMP1 belongs to the TIMP gene family.Metalloproteinase inhibitor 1 encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. TIMP1 is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
    • Function:
    • immune system development, positive regulation of cell proliferation, regulation of catabolic process, negative regulation of catabolic process, negative regulation of macromolecule metabolic process, developmental maturation,hemopoiesis, myeloid cell differentiation, regulation of proteolysis, erythrocyte differentiation, regulation of cellular catabolic process, negative regulation of cellular catabolic process, regulation of cellular protein metabolic process,negative regulation of cellular protein metabolic process, erythrocyte homeostasis, regulation of cell proliferation,regulation of protein catabolic process, negative regulation of protein catabolic process, homeostatic process,erythrocyte maturation, negative regulation of proteolysis, cell maturation, hemopoietic or lymphoid organ development, erythrocyte development, homeostasis of number of cells, regulation of membrane prote
    • Products Images
    • Immunohistochemical analysis of paraffin-embedded human Pancreas. 1,Tissue Inhibitor of Metalloproteinases 1(TIMP1) Antibody was diluted at 1:200(4°,overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval