cadherin pan (PT1718) mouse mAb Ready to use

  • Catalog No.:YM6610R
  • Applications:IHC-p,IF/ICC
  • Reactivity:Human
    • Gene Name:
    • cadherin pan
    • Protein Name:
    • cadherin pan
    • Immunogen:
    • Synthesized peptide derived from human cadherin pan
    • Specificity:
    • This antibody detects endogenous levels of human cadherin pan. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section
    • Formulation:
    • Liquid in PBS containing, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Mouse/IgG1, Kappa
    • Dilution:
    • Ready to use for IHC-p and IF. WB application may demands at least 1:5-20 dilution.
    • Purification:
    • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
    • Storage Stability:
    • 4°C/ 1 years
    • Background:
    • cadherin 1(CDH1) Homo sapiens This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015],
    • Function:
    • disease:Defects in CDH1 are a cause of gastric cancer [MIM:137215]; also known as hereditary familial diffuse gastric cancer (HDGC).,disease:Defects in CDH1 are a cause of susceptibility to endometrial cancer [MIM:608089].,disease:Defects in CDH1 are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases. These typical features relate to the biology of the disease, which is a principal determinant of outcome.,disease:Defects in CDH1 are involved in dysfunction of the cell-cell adhesion system, triggering cancer invasion (gastric, breast, ovary, endometrium and thyroid) and metastasis.,function:Cadherins are calcium dependent cell adhesion proteins.,function:Cadherins are calcium
    • Subcellular Location:
    • Membranous
    • Expression:
    • Brain,Epidermal carcinoma,Hippocampus,Liver,Pancreas,Placenta,Tongue,