Oct-2 (PT0202) mouse mAb Ready to use

  • Catalog No.:YM6141R
  • Applications:IHC-p,IF(paraffin section)
  • Reactivity:Human
    • Gene Name:
    • POU2F2 OCT2 OTF2
    • Protein Name:
    • POU domain, class 2, transcription factor 2 (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2) (Octamer-binding protein 2) (Oct-2) (Octamer-binding transcription factor 2) (OTF-2)
    • Human Gene Id:
    • 5452
    • Human Swiss Prot No:
    • P09086
    • Immunogen:
    • Synthesized peptide derived from human Oct-2
    • Specificity:
    • This antibody detects endogenous levels of human Oct-2. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section
    • Formulation:
    • Liquid in PBS containing, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Mouse/IgG1, Kappa
    • Dilution:
    • IF(paraffin section) 1:50-200 Ready to use for IHC-p
    • Purification:
    • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
    • Storage Stability:
    • 4°C/ 1 years
    • Background:
    • POU class 2 homeobox 2(POU2F2) Homo sapiens The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
    • Function:
    • function:Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.,similarity:Belongs to the POU transcription factor family. Class-2 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,subunit:Interacts with NR3C1, AR and PGR.,tissue specificity:Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line Molt-4, but not in the T-cell line BW 5147.,
    • Subcellular Location:
    • Nuclear
    • Expression:
    • B-cell,B-cell lymphoma,Lymph,