Carcinoembryonic antigen (ABT-CEA) Mouse mAb

    • Catalog No.:YM6026
    • Applications:IHC;WB;ELISA
    • Reactivity:Human
      • Target:
      • CEA
      • Gene Name:
      • CEACAM5 CEA
      • Protein Name:
      • Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e)
      • Human Gene Id:
      • 1048
      • Human Swiss Prot No:
      • P06731
      • Immunogen:
      • Synthesized peptide derived from human carcinoembryonic antigen(CEA) AA range: 600-702
      • Specificity:
      • This antibody detects endogenous levels of human carcinoembryonic antigen(CEA). Antibody is negative with no cross reaction to BGP or NCA. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Mouse, Monoclonal/IgG2b, Kappa
      • Dilution:
      • IHC-p 1:200-400, WB 1:200-1000, ELISA 1:5000-20000
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Molecular Weight(Da):
      • 77kD
      • Background:
      • This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015],
      • Function:
      • function:Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.,PTM:Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.,similarity:Belongs to the immunoglobulin superfamily. CEA family.,similarity:Contains 7 Ig-like (immunoglobulin-like) domains.,subunit:Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.,tissue specificity:Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.,
      • Subcellular Location:
      • Cytoplasmic
      • Expression:
      • Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
      • Products Images
      • Hela whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-CEA(ABT-CEA) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: Hela Predicted band size: 76kDa Observed band size: 200kDa
      • Human colon carcinoma tissue was stained with anti-CEA(ABT-CEA) antibody.
      • Human colon carcinoma tissue was stained with anti-CEA(ABT-CEA) antibody.
      • Human lung adenocarcinoma tissue was stained with anti-CEA(ABT-CEA) antibody.
      • Human pancreatic adenocarcinoma tissue was stained with anti-CEA(ABT-CEA) antibody.