• Target：
• CD206

• Fields：
• >>Phagosome;>>Tuberculosis

• Gene Name：
• MRC1

• Protein Name：
• Macrophage mannose receptor 1

• Human Gene Id：
• 4360

• Human Swiss Prot No：
• P22897

• Mouse Gene Id：
• 17533

• Mouse Swiss Prot No：
• Q61830

• Specificity：
• Synthesized peptide derived from human CD206.AA range:750-850

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Mouse, Monoclonal/IgG1,kappa

• Dilution：
• WB 1:500-2000, ELISA 1:5000-20000

• Purification：
• Protein G

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MRC1;CLEC13D;CLEC13DL;MRC1L1;Macrophage mannose receptor 1;MMR;C-type lectin domain family 13 member D;C-type lectin domain family 13 member D-like;Macrophage mannose receptor 1-like protein 1;CD206

• Molecular Weight(Da)：
• 166kD

• Observed Band(KD)：
• 190kD

• Background：
• The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015],

• Function：
• function:Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.,miscellaneous:CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.,online information:Macrophage mannose receptor,similarity:Contains 1 fibronectin type-II domain.,similarity:Contains 1 ricin B-type lectin domain.,similarity:Contains 8 C-type lectin domains.,

• Subcellular Location：
• Endosome membrane ; Single-pass type I membrane protein . Cell membrane ; Single-pass type I membrane protein .

• Expression：
• Milk,Placenta,Testis,

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