• Target：
• Kininogen 1

• Gene Name：
• MAP2K5 MEK5 MKK5 PRKMK5

• Protein Name：
• MEK5

• Human Gene Id：
• 5607

• Human Swiss Prot No：
• Q13163

• Mouse Gene Id：
• 23938

• Mouse Swiss Prot No：
• Q9WVS7

• Rat Gene Id：
• 29568

• Rat Swiss Prot No：
• Q62862

• Immunogen：
• Synthesized peptide derived from human MEK5

• Specificity：
• This antibody detects endogenous levels of MEK5 at Human, Mouse,Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• Source：
• Mouse,monoclonal

• Dilution：
• WB 1:500-2000

• Purification：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)

• Observed Band(KD)：
• 49kD

• Function：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the OPR domain. This domain also mediates interactions with SQSTM1 and PARD6A.,function:Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.,PTM:Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.,PTM:Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 OPR domain.,similarity:Contains 1 protein kinas

• Expression：
• Expressed in many adult tissues. Abundant in heart and skeletal muscle.

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