FAK Rabbit Polyclonal Antibody

  • Catalog No.:YM3789
  • Applications:IHC-p,IF(paraffin section)
  • Reactivity:Human,Mouse,Rat
    • Gene Name:
    • PTK2 FAK FAK1
    • Protein Name:
    • Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
    • Human Gene Id:
    • 5747
    • Human Swiss Prot No:
    • Q05397
    • Mouse Swiss Prot No:
    • P34152
    • Immunogen:
    • Recombinant Protein of FAK
    • Specificity:
    • The antibody detects endogenous FAK protein
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Rabbit
    • Dilution:
    • IF(paraffin section) 1:50-200 IHC-p 1:50-300
    • Purification:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Other Name:
    • Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
    • Observed Band(KD):
    • 125
    • Background:
    • protein tyrosine kinase 2(PTK2) Homo sapiens This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only four of them have been determined. [provided by RefSeq, Oct 2015],
    • Function:
    • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the localization of FAK1 to focal adhesions.,domain:The first Pro-rich domain interacts with the SH3 domain of CRK-associated substrate (BCAR1) and CASL.,function:Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.,PTM:Phosphorylated on 6 tyrosine residues upon activatio
    • Subcellular Location:
    • stress fiber,nucleus,cytoplasm,microtubule organizing center,cytosol,cytoskeleton,plasma membrane,focal adhesion,cell cortex,apical plasma membrane,lamellipodium,extrinsic component of cytoplasmic side of plasma membrane,
    • Expression:
    • Brain,Epithelium,Hippocampus,Melanocyte,Osteosarcoma,Placenta,Stomach,T-cell,