Smad3 Monoclonal Antibody(6F7)

    • Catalog No.:YM3523
    • Applications:IHC-p,IF(paraffin section)
    • Reactivity:Human,Rat,Mouse
      • Gene Name:
      • SMAD3
      • Protein Name:
      • Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
      • Human Gene Id:
      • 4088
      • Human Swiss Prot No:
      • P84022
      • Mouse Swiss Prot No:
      • Q8BUN5
      • Immunogen:
      • Recombinant Protein of Smad3
      • Specificity:
      • Smad3 protein detects endogenous levels of Smad3
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Mouse
      • Dilution:
      • IF(paraffin section) 1:50-200 IHC 1:100-200
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • SMAD3; MADH3; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3
      • Observed Band(KD):
      • 52
      • Background:
      • SMAD family member 3(SMAD3) Homo sapiens The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009],
      • Function:
      • disease:Defects in SMAD3 may be a cause of colorectal cancer (CRC) [MIM:114500].,domain:The MH2 domain is sufficient to carry protein nuclear export.,function:Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD).,PTM:Phosphorylated on serine by TGF-beta and activin type 1 receptor kinases.,similarity:Belongs to the dwarfin/SMAD family.,similarity:Contains 1 MH1 (MAD homology 1) domain.,similarity:Contains 1 MH2 (MAD homology 2) domain.,subcellular location:In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with Smad4.,subunit:Interacts with HGS. Interacts with NEDD4L in response to TGF-beta. Interacts with TTRAP (By similarity). Interacts with SARA (SMAD anchor for receptor activation); form trimers with another SMAD3 and the co-SMAD SMAD4. Interacts wit
      • Subcellular Location:
      • nuclear chromatin,intracellular,nucleus,nuclear inner membrane,nucleoplasm,transcription factor complex,cytoplasm,cytosol,plasma membrane,receptor complex,SMAD protein complex,SMAD2-SMAD3 protein complex,
      • Expression:
      • Brain,Colon carcinoma,Esophagus tumor,Pancreas,Placenta,Spleen,Umbilical cord blood
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded Human Live rTissue using Smad3(mAb diluted at 1:200.
      • Immunohistochemical analysis of paraffin-embedded Human Colon Carcinoma using Smda3Mouse mAb diluted at 1:200.