CaMKIIβ/γ/δ (Phospho Thr287) Monoclonal Antibody(4H2)

    • Catalog No.:YM3517
    • Applications:IHC-p,IF(paraffin section)
    • Reactivity:Human,Rat,Mouse
      • Immunogen:
      • Synthetic Peptide of CaMKIIβ/γ/δ (Phospho Thr287)
      • Specificity:
      • CaMKIIβ/γ/δ (Phospho Thr287) protein detects endogenous levels of CaMKIIβ/γ/δ (Phospho Thr287)
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Mouse
      • Dilution:
      • IF(paraffin section) 1:50-200 IHC 1:100-200
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • CAMK2B; CAM2; CAMK2; CAMKB; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II subunit beta; CaMK-II subunit beta; CAMK2G; CAMK; CAMK-II; CAMKG; Calcium/calmodulin-dependent protein kinase type II subunit gamma;
      • Observed Band(KD):
      • 50
      • Background:
      • calcium/calmodulin dependent protein kinase II beta(CAMK2B) Homo sapiens The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
      • Function:
      • alternative products:The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different
      • Subcellular Location:
      • nucleoplasm,microtubule organizing center,cytosol,plasma membrane,endocytic vesicle membrane,sarcoplasmic reticulum membrane,
      • Expression:
      • Brain,Insulinoma,Lung,Skeletal muscle,
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using CaMKIIβ/ γ /δ (Phospho Thr287) (mAb diluted at 1:200.
      • Immunohistochemical analysis of paraffin-embedded Mouse Brain Tissue using CaMKIIβ/ γ /δ (Phospho Thr287) Mouse mAb diluted at 1:200.