• Target：
• GFAP

• Fields：
• >>JAK-STAT signaling pathway

• Gene Name：
• GFAP

• Protein Name：
• Glial fibrillary acidic protein

• Human Gene Id：
• 2670

• Human Swiss Prot No：
• P14136

• Mouse Gene Id：
• 14580

• Mouse Swiss Prot No：
• P03995

• Rat Gene Id：
• 24387

• Rat Swiss Prot No：
• P47819

• Immunogen：
• Synthetic Peptide of GFAP

• Specificity：
• The antibody detects endogenous GFAP proteins.

• Formulation：
• PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:2000-5000 IF 1:200 IHC 1:50-300

• Purification：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GFAP;Glial fibrillary acidic protein;GFAP

• Observed Band(KD)：
• 45kD

• Background：
• This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008],

• Function：
• alternative products:Isoforms differ in the C-terminal region which is encoded by alternative exons,disease:Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.,function:GFAP, a class-III intermediate filament, is a cell-spe

• Subcellular Location：
• Cytoplasm . Associated with intermediate filaments. .

• Expression：
• Expressed in cells lacking fibronectin.

Elemene Emulsion Injection Administration Reduces Neuropathic Pain by Inhibiting Astrocytic NDRG2 Expression within Spinal Dorsal Horn. Chinese Journal of Integrative Medicine Chin J Integr Med. 2021 Dec;27(12):912-918 WB Rat 1:1000 Lumbar spinal cord

Effects of altitude changes on mild‑to‑moderate closed‑head injury in rats following acute high‑altitude exposure. Experimental and Therapeutic Medicine 2018 Nov 27 IHC Rat Brain tissues

平昊达, et al. "慢性脑低灌注大鼠焦虑样行为与海马区域炎性细胞因子水平的相关性分析." 收藏 3 (2020).

The analgesic effects of β-elemene in rats with neuropathic pain by inhibition of spinal astrocytic ERK activation: Molecular Pain Jin Zheng WB Rat

Bu Shen Yi Sui Capsule Promotes Myelin Repair by Modulating the Transformation of A1/A2 Reactive Astrocytes In Vivo and In Vitro Oxidative Medicine and Cellular Longevity Lei Wang IHC, IF, WB Mouse, Rat

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