β-Arrestin 1 mouse mAb

    • Catalog No.：YM1514
    • Applications：WB
    • Reactivity：Human
      • Target：
      • Arrestin 1
      • Fields：
      • >>MAPK signaling pathway;>>Chemokine signaling pathway;>>Endocytosis;>>Hedgehog signaling pathway;>>Dopaminergic synapse;>>Olfactory transduction;>>Relaxin signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>GnRH secretion;>>Morphine addiction;>>Chemical carcinogenesis - receptor activation
      • Gene Name：
      • arrb1
      • Human Gene Id：
      • 408
      • Human Swiss Prot No：
      • P49407
      • Mouse Swiss Prot No：
      • Q8BWG8
      • Immunogen：
      • Recombinant human β-Arrestin 1 protein.
      • Specificity：
      • This antibody detects endogenous levels of β-Arrestin 1 and does not cross-react with related proteins.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • wb dilution 1:500
      • Purification：
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -20°C/1 year
      • Other Name：
      • ARB1; ARR1; ARRB1; ARRB1_HUMAN; Arrestin 2; Arrestin beta 1; Arrestin beta-1; Beta-arrestin-1.
      • Observed Band(KD)：
      • 51kD
      • Background：
      • Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011],
      • Function：
      • function:Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.,online information:Arrestin entry,similarity:Belongs to the arrestin family.,
      • Subcellular Location：
      • Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cell projection, pseudopodium . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). .
      • Expression：
      • Brain,Peripheral blood,Uterus,
      • Products Images
      • Western blot detection of β-Arrestin 1 in K562 and Hela cell lysates using β-Arrestin 1 mouse mAb(dilution 1:500).Predicted band size:51kDa.Observed band size:51kDa.

      Attributes

      • Code：
      • YM1514
      • Size
      • 50uL 100ul 200ul
      • Price$：
      • 160 280 450
      • Delivery：
      • 2023-06-14
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