• Target：
• cIAP2

• Fields：
• >>Platinum drug resistance;>>NF-kappa B signaling pathway;>>Ubiquitin mediated proteolysis;>>Apoptosis;>>Apoptosis - multiple species;>>Necroptosis;>>Hippo signaling pathway;>>Focal adhesion;>>NOD-like receptor signaling pathway;>>TNF signaling pathway;>>Salmonella infection;>>Toxoplasmosis;>>Herpes simplex virus 1 infection;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Small cell lung cancer

• Gene Name：
• birc3

• Human Gene Id：
• 330

• Human Swiss Prot No：
• Q13489

• Mouse Swiss Prot No：
• O08863

• Immunogen：
• Purified recombinant human c-IAP2 protein fragments expressed in E.coli

• Specificity：
• This antibody detects endogenous levels of c-IAP2 and does not cross-react with related proteins.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• wb 1:1000

• Purification：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• AIP 1;AIP1;API 2;API2;API2;Apoptosis inhibitor 2;Baculoviral IAP repeat containing 3;Baculoviral IAP repeat containing protein 3;Baculoviral IAP repeat-containing protein 3;BIRC 3;BIRC3;BIRC3;BIRC3_HUMAN;C IAP2;C-IAP2;CIAP 2;CIAP 2;CIAP2;HAIP 1;HAIP1;HAIP1;HIAP 1;HIAP-1;HIAP1;IAP homolog C;IAP-1;Inhibitor of apoptosis protein 1;Inhibitor of apoptosis protein 1;MALT 2;MALT2;Mammalian IAP homolog C;MIHC;MIHC;RING finger protein 49;RNF49;TNFR2 TRAF signaling complex protein 1;TNFR2 TRAF signalling complex protein;TNFR2-TRAF-signaling complex protein 1.

• Observed Band(KD)：
• 72kD

• Background：
• This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011],

• Function：
• disease:A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.,function:Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).,similarity:Belongs to the IAP family.,similarity:Contains 1 CARD domain.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 3 BIR repeats.,subunit:Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.,tissue specificity:Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen,

• Subcellular Location：
• Cytoplasm . Nucleus .

• Expression：
• Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.

CPNE1 silencing inhibits the proliferation, invasion and migration of human osteosarcoma cells. ONCOLOGY REPORTS 2017 Dec 04 WB Human 1:1000 Saos-2 cell

Zhao, Xiumei, et al. "Ruanjian Sanjie Decoction Induces Apoptosis in Triple-negative Breast Cancer Cells by Downregulating cIAP1/2 and XIAP." (2020).

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