• Target：
• Arrestin 1

• Fields：
• >>MAPK signaling pathway;>>Chemokine signaling pathway;>>Endocytosis;>>Hedgehog signaling pathway;>>Dopaminergic synapse;>>Olfactory transduction;>>Relaxin signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>GnRH secretion;>>Morphine addiction;>>Chemical carcinogenesis - receptor activation

• Gene Name：
• arrb1

• Human Gene Id：
• 408

• Human Swiss Prot No：
• P49407

• Mouse Swiss Prot No：
• Q8BWG8

• Immunogen：
• Purified recombinant human beta Arrestin 1 protein fragments expressed in E.coli.

• Specificity：
• This antibody detects endogenous levels of beta Arrestin 1 and does not cross-react with related proteins.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• wb 1:500

• Purification：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ARB 1;ARB 1;ARB1;ARB1;ARR 1;ARR 1;ARR1;ARR1;ARRB 1;ARRB1;ARRB1;ARRB1_HUMAN;Arrestin 2;Arrestin beta 1;Arrestin beta-1;Beta-arrestin-1.

• Observed Band(KD)：
• 50kD

• Background：
• Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011],

• Function：
• function:Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.,online information:Arrestin entry,similarity:Belongs to the arrestin family.,

• Subcellular Location：
• Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cell projection, pseudopodium . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). .

• Expression：
• Brain,Peripheral blood,Uterus,

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