• Target：
• Arrestin-β-2

• Fields：
• >>MAPK signaling pathway;>>Chemokine signaling pathway;>>Endocytosis;>>Hedgehog signaling pathway;>>Dopaminergic synapse;>>Olfactory transduction;>>Relaxin signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>GnRH secretion;>>Morphine addiction;>>Chemical carcinogenesis - receptor activation

• Gene Name：
• ARRB2

• Protein Name：
• Beta-arrestin-2

• Human Gene Id：
• 409

• Human Swiss Prot No：
• P32121

• Mouse Gene Id：
• 216869

• Mouse Swiss Prot No：
• Q91YI4

• Rat Gene Id：
• 25388

• Rat Swiss Prot No：
• P29067

• Immunogen：
• Purified recombinant human Arrestin-β-2 (C-terminus) protein fragments expressed in E.coli.

• Specificity：
• Arrestin-β-2 Monoclonal Antibody detects endogenous levels of Arrestin-β-2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.

• Purification：
• Affinity purification

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ARRB2;ARB2;ARR2;Beta-arrestin-2;Arrestin beta-2

• Molecular Weight(Da)：
• 46kD

• Background：
• Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012],

• Function：
• function:Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.,online information:Arrestin entry,similarity:Belongs to the arrestin family.,

• Subcellular Location：
• Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs.

• Expression：
• Brain,Cord blood,Endometrium,Muscle,Pancreas,Testis,Thyroid,

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