• Target：
• WIF-1

• Fields：
• >>Wnt signaling pathway

• Gene Name：
• WIF1

• Protein Name：
• Wnt inhibitory factor 1

• Human Gene Id：
• 11197

• Human Swiss Prot No：
• Q9Y5W5

• Mouse Swiss Prot No：
• Q9WUA1

• Immunogen：
• Purified recombinant fragment of human WIF-1 expressed in E. Coli.

• Specificity：
• WIF-1 Monoclonal Antibody detects endogenous levels of WIF-1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• WIF1;Wnt inhibitory factor 1;WIF-1

• Molecular Weight(Da)：
• 42kD

• References：
• 1. BMC Cancer. 2009 Jul 1;9:217.
  2. Cancer Res. 2009 Nov 15;69(22):8603-10.

• Background：
• The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010],

• Function：
• function:Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.,similarity:Contains 1 WIF domain.,similarity:Contains 5 EGF-like domains.,

• Subcellular Location：
• Secreted.

• Expression：
• Brain,

Single-Cell RNA Sequencing Reveals the Cellular Origin and Evolution of Breast Cancer in BRCA1 Mutation CarriersThe Cell Origin of BRCA1-Mutated Breast Cancer. CANCER RESEARCH Cancer Res. 2021 May;81(10):2600-2611 IHC Human normal breast tissues

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