• Target：
• IL-1α

• Fields：
• >>MAPK signaling pathway;>>Cytokine-cytokine receptor interaction;>>Necroptosis;>>Cellular senescence;>>Osteoclast differentiation;>>Hematopoietic cell lineage;>>Non-alcoholic fatty liver disease;>>AGE-RAGE signaling pathway in diabetic complications;>>Type I diabetes mellitus;>>Alzheimer disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Pertussis;>>Leishmaniasis;>>Tuberculosis;>>Measles;>>Influenza A;>>Inflammatory bowel disease;>>Rheumatoid arthritis;>>Graft-versus-host disease;>>Fluid shear stress and atherosclerosis

• Gene Name：
• IL1A

• Protein Name：
• Interleukin-1 alpha

• Human Gene Id：
• 3552

• Human Swiss Prot No：
• P01583

• Mouse Swiss Prot No：
• P01582

• Immunogen：
• Purified recombinant fragment of human IL-1a expressed in E. Coli.

• Specificity：
• IL-1α Monoclonal Antibody detects endogenous levels of IL-1α protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• IL1A;IL1F1;Interleukin-1 alpha;IL-1 alpha;Hematopoietin-1

• Molecular Weight(Da)：
• 31kD

• References：
• 1. Du,Y.; et al. 2000. Neurology 55: 480-484.
  2. Grimaldi, L. et al. Ann. Neurol. 47: 361-365, 2000.

• Background：
• The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008],

• Function：
• domain:The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.,function:Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.,online information:Interleukin-1 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the IL-1 family.,subcellular location:The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.,subunit:Mono

• Subcellular Location：
• Cytoplasm . Secreted . The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .

• Expression：
• Lung,

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