• Target：
• Cathepsin A

• Fields：
• >>Lysosome;>>Renin-angiotensin system

• Gene Name：
• CTSA

• Protein Name：
• Lysosomal protective protein

• Human Gene Id：
• 5476

• Human Swiss Prot No：
• P10619

• Mouse Gene Id：
• 19025

• Mouse Swiss Prot No：
• P16675

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PPGB. AA range:277-326

• Specificity：
• Cleaved-Cathepsin A 32k (R326) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin A 32k protein resulting from cleavage adjacent to R326.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CTSA;PPGB;Lysosomal protective protein;Carboxypeptidase C;Carboxypeptidase L;Cathepsin A;Protective protein cathepsin A;PPCA;Protective protein for beta-galactosidase

• Observed Band(KD)：
• 33kD

• Background：
• This gene encodes a member of the peptidase S10 family of serine carboxypeptidases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme. This enzyme possesses deamidase, esterase and carboxypeptidase activities and acts as a scaffold in the lysosomal multienzyme complex. Mutations in this gene are associated with galactosialidosis. [provided by RefSeq, Nov 2015],

• Function：
• catalytic activity:Release of a C-terminal amino acid with broad specificity.,disease:Defects in CTSA are the cause of galactosialidosis [MIM:256540]. It is an autosomal recessive disease.,function:Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.,similarity:Belongs to the peptidase S10 family.,subunit:Heterodimer of a 32 kDa chain and a 20 kDa chain; disulfide-linked.,

• Subcellular Location：
• Lysosome.

• Expression：
• Brain,Liver,Placenta,Platelet,Skin,Uterus,

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