Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in defined oncogenes and tumour suppressor genes (TSG). Two major mechanisms of genomic instability have been identified in sporadic CRC progression. The first, known as chromosomal instability (CIN), results from a series of genetic changes that involve the activation of oncogenes such as K-ras and inactivation of TSG such as p53, DCC/Smad4, and APC. The second, known as microsatellite instability (MSI), results from inactivation of the DNA mismatch repair genes MLH1 and/or MSH2 by hypermethylation of their promoter, and secondary mutation of genes with coding microsatellites, such as transforming growth factor receptor II (TGF-RII) and BAX. Hereditary syndromes have germline mutations in specific genes (mutation in the tumour suppressor gene APC on chromosome 5q in FAP, mutated DNA mismatch repair genes in HNPCC).
Product List
Catalog
Product
Reactivity
Applications
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GSK3β (PT0816R) PT® Rabbit mAb
Human,Mouse,Rat
WB,IHC,IF,IP,ELISA
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GSK3β (Phospho Ser9) (PT0078R) PT® Rabbit mAb
Human,Mouse,
WB,IHC,IF,IP,ELISA
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GSK3β (PTR2553) Mouse mAb
Human,Mouse,Rat,
WB,IHC,IF,ELISA
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GSK3β (Phospho Ser9) (6H6) Mouse mAb
Human,Mouse,Rat
IHC,WB
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GSK3β Rabbit pAb
Human,Mouse,Rat,Rabbit
IF,WB,IHC,IP,ELISA
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GSK3β (Phospho Ser9) Rabbit pAb
Human,Mouse,Rat,Drosophila
IF,WB,IHC,IP,ELISA
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GSK3β (Phospho Ser9) Rabbit pAb
Human,Mouse,Rat
WB,IHC,IF,ELISA
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GSK3β (Phospho Thr390) Rabbit pAb
Human,Rat,Mouse,
WB
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GSK3β Mouse mAb
Human,Mouse
WB,IF,IP
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GSK3β (Phospho Ser9) Cell-Based Colorimetric ELISA Kit
Human,Mouse,Rat
ELISA