MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
Product List
Catalog
Product
Reactivity
Applications
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PTEN (PT0226R) PT® Rabbit mAb
Human,Mouse,Rat,
WB,IHC,IF,IP,ELISA
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PTEN (PT2124) Mouse mAb
Human,
IHC,WB,IF,ELISA
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PTEN Rabbit pAb
Human,Mouse,Rat
IF,WB,IHC,ELISA
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PTEN (Phospho Ser370) Rabbit pAb
Human,Mouse,Rat
WB,IHC,IF,ELISA
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PTEN (Phospho Ser380/Thr382/Thr383) Rabbit pAb
Human,Mouse,Rat
WB,IHC,IF,ELISA
-
PTEN (Phospho Ser385) Rabbit pAb
Human,Mouse,Rat
IHC,IF,ELISA
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PTEN (Acetyl Lys402) Rabbit pAb
Human,Mouse,Rat
WB,ELISA,IHC
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PTEN (Phospho Ser370) Cell-Based Colorimetric ELISA Kit
Human,Mouse,Rat
ELISA
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PTEN (Phospho Ser380/Thr382/Thr383) Cell-Based Colorimetric ELISA Kit
Human,Mouse,Rat
ELISA
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Total PTEN Cell-Based Colorimetric ELISA Kit
Human,Mouse,Rat
ELISA