• 靶点：
• PROZ

• 基因名称：
• PROZ

• 蛋白名称：
• PROZ

• Human Gene Id：
• 8858

• Human Swiss Prot No：
• P22891

• Mouse Gene Id：
• 66901

• Mouse Swiss Prot No：
• Q9CQW3

• 免疫原：
• Synthesized peptide derived from human PROZ AA range: 141-190

• 特异性：
• This antibody detects endogenous levels of Human PROZ

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Vitamin K-dependent protein Z

• 分子量：
• 44kD

• 背景：
• This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012],

• 功能：
• caution:Although homologous with the vitamin K-dependent clotting factors, it has lost two of the essential catalytic residues and has no enzymatic activity.,function:Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 EGF-like domains.,tissue specificity:Plasma.,

• 细胞定位：
• Secreted.

• 组织表达：
• Plasma.

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