• 靶点：
• MAP3K2

• 简介：
• >>MAPK signaling pathway;>>Gap junction;>>GnRH signaling pathway

• 基因名称：
• MAP3K2 MAPKKK2 MEKK2

• 蛋白名称：
• MAP3K2

• Human Gene Id：
• 10746

• Human Swiss Prot No：
• Q9Y2U5

• Mouse Swiss Prot No：
• Q61083

• 免疫原：
• Synthesized peptide derived from human MAP3K2 AA range: 220-300

• 特异性：
• This antibody detects endogenous levels of Human MAP3K2

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:1000-2000 ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25;MAPK/ERK kinase kinase 2;MEK kinase 2;MEKK 2)

• 分子量：
• 68kD

• 背景：
• The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-524.,function:Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 OPR domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Upon EGF stimulation, translocates into the nucleus.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes.,

• 细胞定位：
• Cytoplasm . Nucleus . Upon EGF stimulation, translocates into the nucleus.

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