ANGP2 Polyclonal Antibody

    • 货号:YT6288
    • 应用:WB;ELISA
    • 种属:Human;Rat;Mouse;
      • 靶点:
      • ANGP2
      • 简介:
      • >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>HIF-1 signaling pathway;>>PI3K-Akt signaling pathway;>>Kaposi sarcoma-associated herpesvirus infection
      • 基因名称:
      • ANGPT2
      • 蛋白名称:
      • ANGP2
      • Human Gene Id:
      • 285
      • Human Swiss Prot No:
      • O15123
      • 免疫原:
      • Synthesized peptide derived from human ANGP2
      • 特异性:
      • This antibody detects endogenous levels of human ANGP2
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500-2000, ELISA(peptide)1:5000-20000
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • Angiopoietin-2 (ANG-2)
      • 实测条带:
      • 55kD
      • 背景:
      • The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
      • 功能:
      • function:Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.,online information:Angiopoietin entry,similarity:Contains 1 fibrinogen C-terminal domain.,
      • 细胞定位:
      • Secreted .
      • 组织表达:
      • Colon,Lung,Substantia nigra,Umbilical vein endothelial cell,
      • 产品图片
      • Western blot analysis of various lysates, primary antibody was diluted at 1:1000, 4° over night, secondary antibody(cat: RS23920)was diluted at 1:10000, 37° 1hour.