PDE6G Polyclonal Antibody
- 货号：YT6272
- 应用：IHC;ELISA
- 种属：Human;Mouse
- 简介：
- >>Purine metabolism;>>Metabolic pathways;>>Phototransduction
- 免疫原：
- Synthesized peptide derived from human PDE6G AA range: 10-90
- 特异性：
- This antibody detects endogenous levels of human PDE6G
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IHC 1:50-200, ELISA(peptide)1:5000-20000
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (GMP-PDE gamma;EC 3.1.4.35)
- 背景：
- This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009],
- 功能：
- catalytic activity:Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.,function:Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the rod/cone cGMP-PDE gamma subunit family.,subunit:Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.,
- 细胞定位：
- plasma membrane,photoreceptor disc membrane,
- 组织表达：
- Human retina,Retina,
- Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
