CD206 Polyclonal Antibody

    • 货号:YT5640
    • 应用:WB;IHC;IF;ELISA
    • 种属:Human;Mouse;Rat
      • 靶点:
      • CD206
      • 简介:
      • >>Phagosome;>>Tuberculosis
      • 基因名称:
      • MRC1
      • 蛋白名称:
      • Macrophage mannose receptor 1
      • Human Gene Id:
      • 4360
      • Human Swiss Prot No:
      • P22897
      • Mouse Swiss Prot No:
      • Q61830
      • 免疫原:
      • The antiserum was produced against synthesized peptide derived from the Internal region of human MRC1. AA range:341-390
      • 特异性:
      • CD206 Polyclonal Antibody detects endogenous levels of CD206 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • MRC1;CLEC13D;CLEC13DL;MRC1L1;Macrophage mannose receptor 1;MMR;C-type lectin domain family 13 member D;C-type lectin domain family 13 member D-like;Macrophage mannose receptor 1-like protein 1;CD206
      • 实测条带:
      • 170kD
      • 背景:
      • The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015],
      • 功能:
      • function:Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.,miscellaneous:CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.,online information:Macrophage mannose receptor,similarity:Contains 1 fibronectin type-II domain.,similarity:Contains 1 ricin B-type lectin domain.,similarity:Contains 8 C-type lectin domains.,
      • 细胞定位:
      • Endosome membrane ; Single-pass type I membrane protein . Cell membrane ; Single-pass type I membrane protein .
      • 组织表达:
      • Milk,Placenta,Testis,

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      • 产品图片
      • Western Blot analysis of NIH-3T3 cells using CD206 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
      • Western Blot analysis of 3T3 cells using CD206 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000